This is a professor from Carnegie Mellon who has pancreatic cancer and inevitably will die soon. He is giving his last lecture here and offers some great advice.
There's a more condensed version, only 11 minutes long, from the Oprah show that you can watch here: http://video.stumbleupon.com/?s=ithct48cqw&i=ufcchmyxqsuj9vwsemax
Or check out the whole thing which is almost 80 minutes long. It's worth watching!